Wound healing is a complex process involving the restoration of cellular structures and tissue layers. In many cases, the ability to "cure" a wound can prevent the unnecessary amputation of a limb or part of a limb. At Fountain Plaza Pharmacy, we are able to compound a variety of medications that can help improve the management and healing of wounds. We create customized topical medications with the right combination of active ingredients in the most appropriate base to treat any type of wound.
The choice of treatment delivery can be clinically significant. Gels, which are more water soluble than creams or ointments, may be preferable for wound use because a gel can be rinsed from the wound by irrigations. A polyox bandage can be prepared to contain the active ingredients needed and provide another effective delivery option.
There are numerous types of custom compounded medications that can be used to aid in the treatment of many types of wounds. While there are numerous possible formulations that can be used to treat wounds, these compounds often include:
- Phenytoin - promotes granulation; stimulation of fibroblast proliferation, facilitation of collegen deposition, glucocorticoid antagonism, and antibacterial activity. Phenytoin has been used to treat pressure sores, venous stasis and diabetic ulcers, traumatic wounds, skin graft donor sites, and burns.
- Misprostol - synthetic prostaglandin that accelerates wound healing
- Metronidazole - antibiotic that has effective coverage against many anaerobic organisms and when used topically it can provide control of wound odor
- Nifedipine - blocks calcium influx into smooth muscles, thereby decreasing the vascular tone, which in turn increases blood flow
- Pentoxifylline - increases blood flow and oxygen delivery to the wound site improving circulation and when used topically, it can improve the rate of wound healing by improving the ability of calcium blockers to reach the wound tissue
- NSAIDS (Ketoprofen, Ibuprofen, etc.) - these medications have been demonstrated to inhibit pro-inflammatory enzyme (COX-2) which in turn reduces scar formation and/or thickness when applied topically.